A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria

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A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria.

ABF2 (ARS-binding factor 2), a small, basic DNA-binding protein that binds specifically to the autonomously replicating sequence ARS1, is located primarily in the mitochondria of the yeast Saccharomyces cerevisiae. The abundance of ABF2 and the phenotype of abf2- null mutants argue that this protein plays a key role in the structure, maintenance, and expression of the yeast mitochondrial genome...

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Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1)

The high mobility group (HMG) proteins are the major nonhistone components of chromatin (1). Among these, the HMG1 and HMG2 proteins are the most abundant; however, their precise function remains undefined. There are some indications for a putative role of HMG 1/2 in chromatin assembly (2), DNA replication (3) or even as general transcription factors for RNA polymerase II (4). There is a consid...

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High mobility group 1 protein (HMG1) has traditionally been considered a structural component of chromatin, possibly similar in function to histone H1. In fact, at the onset of Xenopus and Drosophila development, HMG1 appears to substitute for histone H1: HMG1 is abundant when histone H1 is absent after the midblastula transition histone H1 largely replaces HMG1. We show that in early mouse emb...

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ژورنال

عنوان ژورنال: Trends in Cell Biology

سال: 1991

ISSN: 0962-8924

DOI: 10.1016/0962-8924(91)90009-x